"Bruncionum", "Branzonus", "Brianzono", "Brenzono" were the names given to the town over the centuries, probably to indicate the mostly mountainous terrain in the area. "Brenzonum" was first mentioned in two documents from the second half of the 8th century. Afterwards, the historical events of Verona and Garda influenced the development of the town. The castle was destroyed in 1163.
Starting in 1405, Brenzone, Malcesine and Pai formed the northern division of the "Gardesana dell'Acqua" tax district set up by the Venice Republic. The advent of Napoleon (1797) marked the end of Venice's domination and the start of Austrian rule. When the Third War of Independence ended in 1866, Brenzone also became part of the Kingdom of Italy.

Planned by Lil de Kock, the nature trail in Brenzone crosses one of the loveliest areas of the "Riviera of the Olives", a fascinating place in any season. The mule trails that once linked the lakeside villages with the woods, pastures and the "malghe" (alpine farms) of Mount Baldo are now used for marvelous excursions and walks in the midst of a still uncontaminated natural setting.

Brenzone is proud of one of its illustrious fellow citizens, the Blessed Giuseppe Nascimbeni. Born in Torri del Benaco on March 22, 1851, to parents who were natives of Brenzone on lake garda, he was ordained on August 9, 1874. On November 2, 1877, Father Nascimbeni was sent to Castelletto, where he remained until his death.
He first worked there as a teacher and coadjutor vicar, then became the parish priest. He helped establish the local bank, post office and the local olive oil industry. He urged installation of urban lighting and an aqueduct and was responsible for the construction of the oratory, a nursery school, the senior citizens' home and an orphanage.
On November 6, 1892, he founded "Piccole Suore della Sacra Famiglia", a religious congregation that now has 1,370 sisters and hundreds of institutes in Italy and abroad. Father Nascimbeni died on December 31, 1916. Pope John Paul II beatified him on April 17, 1988, during a pastoral visit to Verona.

Mount Baldo has 7 glacial cirques, including ones on the Buse and Telegrafo peaks. The first bowl-shaped cirque is nestled between Cima Costabella (2,062 m) and Vetta delle Buse (2,154 m).
The northern slope is covered by vegetation, while the southern slope is very steep and rocky. The glacial cirque of Telegrafo is double; it includes the cirques of Telegrafo and, further below, that of Valle delle Nogare. Situated between the Cima Scascagna (2,136 m) and Cima Telegrafo (2,200 m) peaks, it has imposing dolomitic rocks with deep grooves caused by ice erosion. A home to interesting flora and fauna, the cirques are easier to reach from the Mondini refuge (1,500 m), which is also accessible by cable car from Prada.

The Town Hall of Brenzone displays a stone slab (3.60 x 1.60 m) that was discovered in 1965 near Castelletto, a short distance from the lake garda. The stone is decorated with many primitive designs dating back to the second millennium B.C. The engravings of axes and daggers arranged at random or in a decorative pattern are proof of an art form that is probably connected with the birth and diffusion of metal working in prehistoric Europe.